our clinical research

Axogen invests in and supports clinical studies and programs to further the understanding and outcomes of peripheral nerve repair.


the RANGER™️ study

A multi-centric, retrospective study of Avance Nerve Graft® utilisation, evaluations and outcomes in peripheral nerve injury repair (RANGER). The RANGER study, the Avance Nerve Graft registry, has completed the second data milestone and continues to enrol.

the CHANGE study

A multi-centre, prospective, randomised, comparative study of hollow nerve Conduit and Avance Nerve Graft evaluation recovery outcomes of the nerve repair in the hand (CHANGE). The CHANGE study is a pilot comparative study. Enrolment and follow-up is now complete and the study has been published (Means KR, Rinker BD, Higgins JP, et al.) A multicenter prospective randomised pilot study of outcomes for digital nerve repair in the hand using hollow conduit compared with processed nerve allograft. Hand. 2016;11(2):144-151. doi:10.1177/1558944715627233.).

the RECON study

A multi-centric, prospective, randomised, subject and evaluator blinded comparative study of nerve cuffs and Avance Nerve Graft evaluating recovery outcomes for the repair of nerve discontinuities (RECON). The primary objective of this study is to evaluate the difference in functional recovery outcomes between the study groups. Enrolment is now complete and follow-up activities are continuing.

the MATCH™️ study

A contemporary cohort control for the RANGER study, MATCH provides reference controls for nerve auto graft and manufactured conduits from participating registry centres. MATCH data milestones have been presented and the cohorts are actively enrolling.


Sensation Neurotisation Outcomes for Women, or Sensation-NOW, is an arm of the RANGER study focused on the breast neurotisation procedure and the impact of restoration of sensory function.

the ANG-CP-003 study

Cavernous nerve reconstruction using Avance Nerve Graft in subjects who undergo robotic assisted prostatectomy for treatment of prostate cancer. This study is being conducted to assess the technical feasibility of robotic assisted implantation of Avance Nerve Graft and the long-term outcomes for continence and potency in men undergoing radical prostatectomy. This study is now completed.

*Nerve repair solutions are extensively studied. The bibliography contains publications across a variety of nerve repair solutions. Axogen is providing this bibliography for awareness and educational purposes. New publications are added continuously. The bibliography does not claim to be complete. Click here for a PDF version of the peripheral nerve repair bibliography.

Disclaimer: Not all products are available in every country.

This webpage is intended for healthcare professionals.

Are you a licensed healthcare provider?